Whole-genome sequencing of early neoplasias and related carcinomas from archival material

In order to elucidate the role of early neoplasias in cancer evolution we performed comparative whole genome sequencing of early neoplasias, matched normal tissue, and carcinomas from six patients. By using somatic mutations as lineage markers we built trees that relate the tissue samples within each patient. On the basis of these lineage trees we inferred the order, timing, and rates of genomic events.