<b>Transmission and hedge balance of virus-encoded cholera toxin genes in global habitats</b>

Cholera is a highly contagious disease caused by Vibrio cholerae, which endangers human health, causes economic losses and overwhelms public health services. Although the impact of Vibrio cholerae on human health has been extensively studied, limited information is available about the acquisition and transmission of cholera toxin genes by V. cholerae across different environments. In this work, we investigated the transferring of cholera toxin genes between viruses and bacteria from different habitats by collecting viral and bacterial genomes containing the cholera toxin genes from IMG/VR, Refseq, and Enterobase databases.霍乱是由霍乱弧菌（Vibrio cholerae）引发的高传染性疾病，其不仅危害人类健康、造成经济损失，还会给公共卫生服务体系带来沉重负担。尽管学界已针对霍乱弧菌对人类健康的影响开展了广泛研究，但目前关于不同环境中霍乱弧菌获取和传播霍乱毒素基因的相关信息仍较为有限。本研究通过从IMG/VR、RefSeq及Enterobase数据库中采集携带霍乱毒素基因的病毒与细菌基因组，探究了不同生境下病毒与细菌之间的霍乱毒素基因转移情况。