SL-C-AMm-20210330-0031

Inflammatory bowel disease (IBD) is a chronic inflammatory disease with an increasing incidence year by year, and its pathogenesis may be related to factors such as dysbiosis of intestinal flora. Miao sour soup (MSS), a fermented food for daily consumption in Guizhou, China, is rich in microorganisms with many excellent activities, including anti-inflammatory and antioxidant activities. However, the therapeutic effects of MSS on IBD remain to be explored. The aim of this study was to investigate the protective effect of MSS against colitis in mice In this study, we investigated the community structure of MSS and the protective role of MSS in against dextran sulfate sodium salt (DSS)-induced colitis in mice. In this study, we examined the microbial community structure of MSS by metagenomic sequencing, and also explored the protective effect of MSS on DSS induced colitis in mice. We investigated the effects of MSS on intestinal inflammatory response and intestinal barrier function in mice. Finally, the changes of intestinal flora were analyzed based on the results of 16S rRNA gene sequencing.The results showed that MSS contained a variety of probiotics.