WP3969 - H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer - Homo sapiens
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In this proposed model, H19 interacts with macroH2A, and this may consequently lead to de-repression of genes including CDK8, CDK4, and CCND1. Increased CDK4-cyclin D1 complex phosphorylates Rb to disrupt Rb-E2F1 interaction, leading to E2F1 activation. The increase of CDK8 expression enhances the function of mediator complex including MED1, and facilitates the gene regulation by beta-catenin. These downstream targets could work in a synergistic way of promoting cell proliferation and increasing cell motility in colorectal cancer.
[Reference](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264449/)
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3969).
创建时间：
2025-04-17
