Proteomics and phosphoproteomics reveal dysregulated kinases and associated pathway in liver fibrosis

Liver fibrosis is the initial stage of most liver diseases, and it is also a pathological process involving the liver in the late stages of many metabolic diseases. Therefore, it is important to systematically understand the pathological mechanism of liver fibrosis and seek therapeutic approaches for intervention and treatment of liver fibrosis. Disorder proteins and their post-translational modifications such as phosphorylation play vital roles in the occurrence and development of liver fibrosis, however, the regulatory mechanisms are not fully understood. In this study, we analyzed and quantified the liver proteome and phosphoproteome of CCl4-induced early liver fibrosis in mice.