Gold(III) Chloride-Catalyzed Three-Component Reaction: A Facile Synthesis of Alkynyl Derivatives of 1,2-Dihydroquinolines and Isoquinolines

Gold(III) chloride is found to be an effective catalyst
for the addition of alkynes on activated quinoline/isoquinolines to
produce a series of alkynyl-substituted 1,2-dihydroquinolines and
isoquinolines in a single-step operation. The easy availability of
starting materials, convenient synthetic procedure, operational simplicity,
and high regioselectivity makes this strategy very useful for the
preparation of enyne derivatives of aza-aromatic compounds.