Transcriptional profile of lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) tumors from KRasG12D; Fbw7f/f mice. Transcriptional profile of lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) tumors from KRasG12D; Fbw7f/f mice

We performed lung ADC and SCC transcriptome profiling from KRasG12D; Fbw7f/f murine lung tumors by RNA-seq and compared them with a consensus lung SCC signature using data from two different SCC models (Lkb1f/f; Ptenf/f, Cancer Cell 2014 and LSL-Sox2; Ptenf/f; Cdkn2abf/f, Cancer Cell 2016) that has been validated in human lung SCC Overall design: Transcriptome profiles of lung adenocarcinoma and squamous cell carcinoma were generated by deep sequencing, in triplicate (primary tumors) or duplicate (primary cells).