Kinetic constants used for simulations.

aOscillatory condition. b26 logarithmically equally spaced points between 0.028118 and 10 ̂1. c0.003 was used for the basal production rate of p53 in the absence of DNA damage. 0.01 was used for the basal production rate of p53 in the presence of DNA damage because the rate of p53 translation is increased after DNA damage. (Takagi et al., 2005). d50 logarithmically equally spaced points between 10̂-3 and 1. e50 logarithmically equally spaced points between 10̂-5 and 10̂1. f40 logarithmically equally spaced points between 10̂-3 and 10̂0.7. g[0 0.05 5] h[0.0001, 0.001, 0.005, 0.01, 0.02, 0.05, 0.075, 0.1, 0.5, 1, 2, 8, 10, 12, 20] i10 logarithmically equally spaced points between 10̂-5 and 20.0. jk33 in figure 2-A. kThe reaction was used with time delay, 50. lk33 in figure 2-B. NA indicates that the interaction is not included.