Variant combinitorials versus drug activity correlationa.

aInput compounds (Figure 4A and Table S3) and amino acid changing variants compared by Matthew's correlation coefficient.bNational Service Center identifier.cDrug mechanism of action abbreviations: A7 is alkylating at N-7 position of guanine; Apo is apoptotic, Db is DNA binder; DNMT is DNA methylttransferase inhibitor; Ds is DNA synthesis inhibitor; PKC is protein kinase C inhibitor; STK is serine threonine kinase; T1 is topoisomerase 1 inhibitor; T2 is topoisomerase 2 inhibitor; and YK is tyrosine kinase inhibitor.dMatthew's correlation coefficient.