One-Pot Asymmetric Nitro-Mannich/Hydroamination Cascades for the Synthesis of Pyrrolidine Derivatives: Combining Organocatalysis and Gold Catalysis
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/One_Pot_Asymmetric_Nitro_Mannich_Hydroamination_Cascades_for_the_Synthesis_of_Pyrrolidine_Derivatives_Combining_Organocatalysis_and_Gold_Catalysis/2028486
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资源简介：
The highly enantioselective preparation
of trisubstituted pyrrolidine
derivatives employing a one-pot nitro-Mannich/hydroamination cascade
is reported. This cascade approach utilizes an asymmetric bifunctional
organocatalytic nitro-Mannich reaction followed by a gold-catalyzed
allene hydroamination reaction. The products are afforded in good
yields and excellent diastereo- and enantioselectivities.
创建时间：
2015-12-17
