Association of Uremic Solutes with Outcomes among 394 Hemodialysis Participants of the CHOICE Study.

Abbreviations: HR, Hazard Ratio; CI, Confidence Interval. Hazard ratio per 1 standard deviation increase in the solute level modeled using Cox proportional hazards regression. 1 Model 1: Crude model without adjustment. 2 Model 2: Minimally adjusted: HR adjusted for demographics (age, sex and race). 3 Model 3: Fully adjusted: HR adjusted for demographics (age, sex and race), clinical characteristics [body mass index, residual kidney function (self-reported ability to produce >1 cup of urine daily), Index of Coexistent Disease (ICED) score, diabetes and cardiovascular disease] and laboratory tests (Kt/VUREA, albumin, phosphate and creatinine). Note: Mean (Standard Deviation) for the free solutes are: P-cresol sulfate 0.196 (0.128) mg/dL; Indoxyl Sulfate 0.126 (0.100) mg/dL; Hippurate 1.5 (2.1) mg/dL and Phenylacetylglutamine 2.3 (1.7) mg/dL. Association of Uremic Solutes with Outcomes among 394 Hemodialysis Participants of the CHOICE Study.