Investigating the Molecular Impact of Titanium Micro-Particles in Dental Implant Failure
收藏ESRF Portal2027-01-01 更新2026-04-23 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-ES-1915451522
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资源简介：
Peri-implantitis is a multi-factorial complication arising in about 20 % of dental implants (2 Mio implants globally/year), leading to inflammation, bone loss and eventual implant loss. While titanium wear particles are suspected contributing factors, their biological potential in peri-implantitis remains unclear. The present project aims to study the molecular response to titanium micro-particles in human peri-implant tissue regions using an innovative integration of X-ray computed microtomography (µCT) with liquid chromatography-tandem mass spectrometry (LC-MS/MS), in high throughput. µCT will allow for the localization of the three-dimensional particle distribution within tissue biopsies, while LC-MS/MS will enable the identification of protein-level changes induced by titanium particles. This approach will aid in understanding the impact of titanium particles in peri-implantitis pathogenesis and pave the way for modifications of implant surfaces and targeted interventions.
提供机构：
University Hospital, Dept. of Oral- and Maxillofacial Surgery, Hugstetter Str. 55, 79100 Freiburg, Germany; Medical Center - University of Freiburg, Institute for Surgical Pathology, Breisacher Straße 115a, 79106 Freiburg, Germany; Xploraytion GmbH, Basic Research, Invalidenstrasse 34, 10115 Berlin, Germany
创建时间：
2027-01-01
