Ruthenium(II)-Catalyzed C–C/C–N Coupling of 2‑Arylquinazolinones with Vinylene Carbonate: Access to Fused Quinazolinones

In
this work, ruthenium­(II)-catalyzed C–C/C–N annulation
of 2-arylquinazolinones with vinylene carbonate is reported to synthesize
fused quinazolinones. This catalytic system tolerates a wide range
of substrates with excellent functional-group compatibility. In this
transformation, the vinylene carbonate acts as an ethynol surrogate
without any external oxidant involved. Furthermore, preliminary mechanistic
studies were conducted, and a plausible catalytic cycle was also proposed.