Synthetic dual-costimulation for TCR and TCR-like targeted cell therapies. Synthetic dual-costimulation for TCR and TCR-like targeted cell therapies

To characterize the phenotype of human HIT T-cells endowed with a novel synthetic co-stimulatory molecule isolated from a mouse xenograft model compared to a control. Overall design: human CD45+ cells were isolated at day 9 post injection from bone marrows of tumour-bearing mice treated with HIT T-cells. Experimental and control samples were hash-tagged and pooled for single cell RNAseq.