Foxp1 developing neocortex (snRNA-Seq)

The transcription factor Foxp1 is expressed in the neocortex with restricted patterns across development. We used single nuclei-RNA sequencing (snRNA-Seq) to determine the cell-type roles of Foxp1 in control and Foxp1 conditional knock-out animals generated by crossing to Emx1.Cre hemizygous mice. Samples were collected at embyonic day (E)13.5, E16.5, and post-natal day (P)0.5. The transcription factor Foxp1 is expressed in the neocortex with restricted patterns across development. We used single nuclei-RNA sequencing (snRNA-Seq) to determine the cell-type roles of Foxp1 in control and Foxp1 conditional knock-out animals generated by crossing to Emx1.Cre hemizygous mice. Samples were collected at embryonic day (E)13.5, E16.5, and post-natal day (P)0.5.转录因子Foxp1在新皮层中表达，且在整个发育进程中呈现受限的表达模式。本研究采用单细胞核RNA测序（single nuclei-RNA sequencing，snRNA-Seq），以明确Foxp1在对照组以及通过与Emx1.Cre半合子小鼠杂交构建的Foxp1条件性敲除动物中的细胞类型层面的功能。样本分别采集于胚胎第（E）13.5天、E16.5天以及出生后第（P）0.5天。转录因子Foxp1在新皮层中表达，且在整个发育进程中呈现受限的表达模式。本研究采用单细胞核RNA测序（snRNA-Seq），以明确Foxp1在对照组以及通过与Emx1.Cre半合子小鼠杂交构建的Foxp1条件性敲除动物中的细胞类型层面的功能。样本分别采集于胚胎第（E）13.5天、E16.5天以及出生后第（P）0.5天。