Data Repository for Beat AML Drug Combo

This repository contains the raw and processed data and analysis outputs used in the article: Integrating drug combination landscapes with multiomics for acute myeloid leukemiaXiao Xian Lin, Christopher A. Eide, Stephen E. Kurtz, Elyse A. Olesinski, Shradha Garnaik, Vedant Sandhu, Nicola Long, Rucha Ravi Kulkarni, Noor Rashidha Binte Meera Sahib, Melissa Ooi, Edward K. Chow, Jeffrey W. Tyner, Sanjukta Das, Shruti Bhatt Sources of published raw and derived data Patient sample clinical summary, RNA-sequencing data, WES/targeted sequencing mutations calls and raw inhibitor values from the Beat AML cohort are downloaded from publicly accessible interactive user interface, Vizome and Github page. Processed Beat AML global proteomics data are accessed via the Synapse repository from Pacific Northwest National Laboratory - Proteogenomic Translational Research Center, and are available under restricted access. The Functional Precision Medicine Tumor Board data from University of Helsinki are downloaded from their publicly accessible Zenodo repository. Processed and raw single cell RNA sequencing data are accessed via GEO under GSE116256. Processed DNA methylation data is accessed via GEO under GSE159907. The original code for replicating the paper analysis is deposited at GitHub. All data generated can be interactively accessed through our browser.