COMPASS ICI response prediction dataset

This record contains the <b>Immunotherapy Response Patient (ITRP)</b> dataset used for downstream fine-tuning and validation of the <b>COMPASS</b> foundation model.The dataset aggregates <b>1,133 patients</b> from <b>16 published immunotherapy cohorts (</b>including RNA-seq TPM matrices, clinical annotations, and response labels.<b>)</b>, spanning melanoma, bladder, renal, lung, gastric, and brain cancers. Each patient received immune checkpoint inhibitors (anti–PD-1, anti–PD-L1, or anti–CTLA-4).<b>Contents</b>The ZIP archive includes two pandas pickle files:<b>ITRP.TPM.TABLE</b> — gene-level RNA-seq TPM matrix across 1,133 patients.<b>ITRP.PATIENT.TABLE</b> — clinical metadata table containing cancer type, treatment, and response labels (responder vs. non-responder).These files were preprocessed and harmonized using the official COMPASS data-processing pipeline to ensure consistent gene naming, normalization, and cohort integration.<br>Documentation and preprocessing scripts are available at:<br>🔗 https://www.immuno-compass.com/help/index.html#datasets<br>🔗 https://github.com/mims-harvard/COMPASS-web/tree/main/TCGA_dataset_processing<b>Data access</b>Due to data-sharing and privacy regulations, the underlying patient-level data were originally obtained from controlled repositories such as <b>EGA</b>, <b>dbGaP</b>, and <b>ENA</b>.<br>Redistribution is restricted; users should request access from the corresponding repositories or original publications.