A microRNA cluster in the DLK1-DIO3 imprinted region on chromosome 14q32.2 in hepatoblastoma. A microRNA cluster in the DLK1-DIO3 imprinted region on chromosome 14q32.2 in hepatoblastoma

Using array-based expression analysis on formalin-fixed paraffin-embedded tissues, we aimed to identify miRNA signatures that can discriminate between lung metastatic tumors, primary tumors (fetal and embryonal subtypes) and nontumorous surrounding livers. A large cluster of microRNAs and snoRNAs located within the 14q32.2 DLK1-DIO3 region showed a strikingly upregulated expression pattern in HB tumors, especially metastatic tumors, compared to normal liver tissues. Overall design: Here we examined microRNAs and snoRNAs profiles related to different type of hepatoblastoma tumor cells, using array-based expression analysis.