Investigating the role of Foxp1 in murine A20 lymphoma cells
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https://www.ncbi.nlm.nih.gov/sra/SRP227349
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Purpose: to investigate the role of transcription factor Foxp1 in murine A20 lymphoma cells, which can be used as a model for human diffuse large B cell lymphoma Method: Exons 6 and 7 of Foxp1 were independently targeted using CRISPR/Cas9 editing, and 2 clones from each targeted exon (E6 and E7), showing depleted Foxp1 isoforms were isolated. Method: RNA sequencing was conducted on parental A20 cells and CRISPR clones, and differential gene expression was undertaken Overall design: The mRNA fraction of total RNA from A20 parental cells and two independent CRISPR clones was sequenced in triplicate using Illumina HiSeq4000
创建时间：
2020-04-28
