National Genomic Research Library

The National Genomic Research Library (NGRL) is a secure database and bioresource managed by Genomics England in partnership with the NHS. The NGRL contains participants’ health data collected by the NHS as part of their care, along with samples and data from their participation in research, for which fully informed consent has been obtained. This includes genomic and clinical data provided through the NHS Genomic Medicine Service, as well as data obtained through research studies including the 100,000 Genomes Project and the Generation Study, both of which are delivered in partnership with the NHS, and from other research cohorts involving external collaborators.<br><br>The NGRL Governance Framework establishes how access to the NGRL is governed, following the "Five Safes" principles to protect participant confidentiality whilst enabling research to advance healthcare. The NGRL Governance Framework v6 supersedes the NGRL Protocol v5.1.<br><br>For more information on how to access the NGRL, visit: https://www.genomicsengland.co.uk/research国家基因组研究库（National Genomic Research Library，NGRL）是由英国基因组学（Genomics England）与英国国民保健制度（National Health Service，NHS）合作管理的安全数据库与生物资源库。该库收录了英国国民保健制度（NHS）在受试者常规诊疗过程中收集的健康数据，以及受试者参与研究项目所提供的生物样本与相关数据，所有样本与数据均已获得受试者的完全知情同意。其中涵盖通过英国国民保健制度基因组医学服务（NHS Genomic Medicine Service）提供的基因组与临床数据，同时也包含来自10万人基因组项目（100,000 Genomes Project）与世代研究（Generation Study）等研究项目的数据——这两项研究均与英国国民保健制度（NHS）合作开展——以及来自外部合作者参与的其他研究队列的数据。 国家基因组研究库治理框架（NGRL Governance Framework）明确了该库的访问管理规则，其遵循“五项安全”（Five Safes）原则，在严格保护受试者隐私的同时，支持研究以推进医疗健康事业发展。版本6的国家基因组研究库治理框架取代了版本5.1的国家基因组研究库规程（NGRL Protocol v5.1）。 如需了解更多关于申请访问国家基因组研究库的相关信息，请访问：https://www.genomicsengland.co.uk/research