Characterization of imprinted methylation using the Illumina Infinium MethylationEPIC array platform
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103738
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资源简介：
Bisulphite (BS) converted DNA from 2 paternal uniparental diploidies (pUPDs), one maternal (mUPD) and 5 control leukocytes samples were hybridized to the Infinium HumanMethylationEPIC BeadChip (Illumina), obtaining the BS DNA methylation profiles across approximately 850,000 CpGs. In addition, the 5 control leukocyte samples were also coverted using oxidative bisulphite (oxBS) treatment. The selective chemical oxidation of 5-hydroxymethylcytosine (5hmC) to 5-formylcytosine (5fC) and the deamination of the latter to uracil during the BS conversion allowed the quantification of independent 5-methylcytosine (5mC) and 5hmC methylation levels at every single CpG. Bisulphite converted DNA from 3 reciprocal uniparental diplodies were hybridised to the Infinium HumanMethylationEPIC BeadChip (Illumina) together with bisulphite and oxidative bisulphite converted DNA from 5 control leukocytes.
创建时间：
2021-07-25
