Additional file 1 of Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles

Additional file 1: Table S1: Sample demographic information for the discovery and replication samples and the individual APOE genotype groups within the discovery sample. Table S2. Differentially methylated positions (DMPs) showing replicated association with APOE ε4 vs. ε2 carrier status and sensitivity analyses results. Table S3. Pairwise comparison of DNA methylation levels between APOE genotypes for each of the 20 CpGs identified as being a DMP in the meta-analysis of the discovery and replication samples. Table S4. Gene ontology (GO) terms showing significant enrichment (P ≤ 2.21 × 10−6) for the CpG sites identified as showing suggestive (P ≤ 1 × 10−5) association with APOE ε4 vs. ε2 carrier status through DMP analysis or which contributed to a significant DMR. Table S5. Assessment of total, HDL or non-HDL cholesterol as potential mediators of APOE ε4 vs. ε2 carrier status on methylation. Table S6. meQTLs for the APOE ε4 vs. ε2-associated DMPs and DMR sites. Table S7. meQTLs for APOE ε4 vs. ε2-associated DMPs and DMR sites grouped by genomic region. Table S8. GWAS catalogue entries for the meQTLs associated with the APOE ε4 vs. ε2-associated DMPs and DMR sites.