Genome_Evolution_to_Environmental_Stress_in_Fission_Yeast

We carried out experimental evolution assays during which fission yeast populations were repeatedly exposed to short heat-shocks, followed immediately by ideal growth conditions. Samples were frozen after each selection cycle for subsequent phenotypic and genotypic analyses. Surprisingly, in all experiments except for the mock-treated control, cells acquired a markedly increased resistance to heat and other stresses within only 10-20 selection cycles, while during later cycles there was a subtle and gradual additional increase in resistance. To get the most from these experimental samples, we plan to sequence 200 yeast genomes, This will provide sufficient breath and depth of data to carry out powerful analyses into intriguing questions of genome evolution and the complex relationships between genotype, phenotype and environment. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/