Tumours and Lifespan in Rats After Irradiation From Neutrons or Co-60 Gamma Rays and Treatment with Chemicals

Purpose: To evaluate the influence of cofactors on the effects from Triton neutrons or gamma rays.

Status: 1982 - 1985, terminated; data in ERAD except for unavailable groups indicated in italics

Treatment: Exposure at the TRITON facility (fission neutrons 0.01-0.1 Gy/h) Silène reactor: see under 02.12 Co-60 source: (0.12 Gy/min)

Dosimetry: Neutrons: Carbon coated ionization chamber, Gamma source: Ionization chamber

Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology

Animal: Male Sprague-Dawley SPF rats at an age of 3 months, one experiment with Wistar rats ; for general controls see 02.01, for controls treated with BNF see 02.04, for controls with high dose neutron exposure only see 02.13.

Results: The only significant differences found in this study was an increase in lung cancers when BNF was used as cofactors