Transcriptional signatures of progressive neuropathology in tau and amyloid mouse models. Transcriptional signatures of progressive neuropathology in tau and amyloid mouse models

Using highly-parallel RNA-sequencing on samples from rTg4510 and J20 mice (n = 121 mice), collected at four different time points, we profiled transcriptional changes in the entorhinal cortex paralleling the progression of Alzheimer's disease-associated pathology. Overall design: Highly parallel RNA-seq of the entorhinal cortex at four time points in transgenic (rTg4510 and J20) and wild type littermate control mice (n=121)