Periplaneta Americana (L.) extract promotes ischemic stroke recovery by inhibiting inflammasome activation

Ischemic stroke (IS) remains a devastating cardiovascular disease with high mortality rates and limited treatment options. Current therapeutic approaches face significant challenges in reducing brain injury and promoting neuronal repair post-stroke. While endovascular thrombectomy has shown promise, its narrow treatment window and potential reperfusion injury underscore the urgent need for alternative therapeutic strategies. In this study, we investigate the therapeutic potential of PAS840, an extract from Periplaneta americana (L.), in treating ischemic stroke by examining its components, predicting its targets, and validating its effects on key pathological processes involved in stroke progression.

缺血性卒中（IS）作为一种致命的心血管疾病，其死亡率高，治疗选择有限。目前的治疗方法在减轻脑损伤和促进卒中后神经元修复方面面临着重大挑战。尽管经血管内血栓切除术显示出一定的前景，但其狭窄的治疗窗口和潜在的再灌注损伤凸显了寻找替代治疗策略的迫切需求。在本研究中，我们探讨了来自美洲蟑螂（Periplaneta americana (L.)）提取物 PAS840 的治疗潜力，通过分析其成分、预测其靶标以及验证其对卒中进展过程中关键病理过程的影响，以治疗缺血性卒中。