Pirin dampens the proliferation of malignant cells by downregulating JARID1B/KDM5B expression. human skin metagenome

Pirin was first described as a ubiquitously expressed nuclear protein that putatively acted as a transcriptional co-factor. However, recent evidence emerged indicating that this protein is involved in tumorigenesis and the malignant progression of several tumors. Primary melanocytes in which PIR was silenced were screening by RNA sequencing.