P2Y2 receptor binds ATP and UTP

The P2Y2 receptor (Parr CE et al, 1994) is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene. The effects of P2Y2 are mediated by coupling with the G protein alpha Gq/11 subunits (Schachter JB et al, 1997). P2Y2 is a potential drug target for treating cystic fibrosis (Kellerman D et al, 2002).

P2Y2受体（Parr CE 等人，1994年）对腺苷和尿苷核苷均具有反应性。该受体可能参与调控子宫内膜癌细胞周期的控制。针对该基因，已鉴定出三种编码相同蛋白质的转录变体。P2Y2的作用通过与其G蛋白αGq/11亚基的偶联来实现（Schachter JB 等人，1997年）。P2Y2是治疗囊性纤维化疾病的潜在药物靶点（Kellerman D 等人，2002年）。