Underlying data for figures – Part 2: high fat diet (HFD).

Data supporting “The KCNJ11-E23K gene variant reduces glucose tolerance
and accelerates diet-induced diabetes progression in mice by impairing
glucose-induced insulin secretion”.
Underlying data for figures – Part 2: high fat diet (HFD).
Figure 5 - Data on the body weight gain on a HFD of female and male mice carrying two risk alleles (KK) or none (EE), from 3 to 23 weeks of age. At 8 weeks of age animals were switched from a standard to a HFD.
Supp. Figure 4 - Data on the fed blood glucose concentration of female and male mice carrying two risk alleles (KK) or none (EE), from 7 to 17 weeks of age (HFD from week 8).
Supp. Figures 5,6 and 7 – File 1: Glucose data on the IPGTT of female and male mice carrying two risk alleles (KK) or none (EE), at 12 weeks of age, after 4 weeks on a HFD. File 2: Data on the plasma insulin concentrations measured during the IPGTT. Mouse numbering is consistent between file 1 and 2.
Figure 6A - Glucose data on the IPITT of female and male mice carrying two risk alleles (KK) or none (EE), on a HFD at 16 weeks of age.
Figures 6B,6C & 6D and supplemental figures 8 & 9 – File 1: Glucose data on the IPGTT of female and male mice carrying two risk alleles (KK) or none (EE), at 26 weeks of age, after 18 weeks on a HFD. File 2: Data on the plasma insulin concentrations measured during the IPGTT. Mouse numbering is consistent between file 1 and 2.
Figure 7 - Data on haemoglobin glycation of female and male mice carrying two risk alleles (KK) or none (EE), at 28 weeks of age (HFD from week 8).
Figure 8 - Data on glucose stimulated insulin secretion per islet (file 1), on the islet insulin content (file 2) and on glucose/sulfonylurea-stimulated insulin secretion, normalized to insulin content (file 3). Pancreatic islets were isolated from female and male mice, carrying two risk alleles (KK) or none (EE), at 23 weeks of age (HFD from week 8).