Catalytically Generated Ferrocene-Containing Guanidines as Efficient Precursors for New Redox-Active Heterometallic Platinum(II) Complexes with Anticancer Activity
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https://figshare.com/articles/dataset/Catalytically_Generated_Ferrocene_Containing_Guanidines_as_Efficient_Precursors_for_New_Redox_Active_Heterometallic_Platinum_II_Complexes_with_Anticancer_Activity/2106409
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资源简介：
The
potential of structurally new ferrocene-functionalized guanidines
as redox-active precursors for the synthesis of heterometallic platinum(II)–guanidine
complexes with anticancer activity was studied. To this end, an atom-economical
catalytic approach was followed by using ZnEt2 to catalyze
the addition of aminoferrocene and 4-ferrocenylaniline to N,N′-diisopropylcarbodiimide. Furthermore,
reaction of a platinum(II) source with the newly obtained guanidines
Fc–NC(NHiPr)2 (3) and Fc(1,4-C6H4)–NC(NHiPr)2 (4) provided access to the heterometallic
complexes [PtCl2{Fc–NC(NHiPr)2}(DMSO)] (5), [PtCl2{Fc(1,4-C6H4)–NC(NHiPr)2}(DMSO)] (6), and [PtCl2{Fc(1,4-C6H4)–NC(NHiPr)2}2] (7). Electrochemical studies evidence the remarkable
electronic effect played by the direct attachment of the guanidine
group to the ferrocene moiety in 3, making its one-electron
oxidation extremely easy. Guanidine-based Fe–Pt complexes 5 and 6 are active against all human cancer cell
lines tested, with GI50 values in the range 1.4–2.6
μM, and are more cytotoxic than cisplatin in the resistant T-47D
and WiDr cell lines.
创建时间：
2016-02-12
