Modulation of HDR efficiency by cell cycle synchronization

NIAID Data Ecosystem2026-05-01 收录

DNA修复调控

小分子药物

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https://www.ncbi.nlm.nih.gov/sra/SRP451411 数据链接链接失效反馈

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Testing 4 small molecules (docetaxel, nocodazole, irinotecan and mitomycin C) for their ability to regulate HDR DNA repair effect.

创建时间：

2024-02-24

Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate

蛋白质-配体复合物结构

小分子药物

Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate Descriptor: 1,1,1,3,3,3-hexafluoro-2-{4-[4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... Authors

Protein Data Bank Japan2024-02-28 更新40

BindingDB Entry 50018444: Progress in PD-1/PD-L1 pathway inhibitors: From biomacromolecules to small molecules.

免疫检查点抑制剂

小分子药物

Small molecule binding data for protein Platelet-derived growth factor receptor alpha/beta, Programmed cell death 1 ligand 1, and Programmed cell death 1 ligand 2, Uniprot P05622, P26618, Q9BQ51, Q9EP

DataCite Commons2024-04-26 更新30

Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators

小分子药物

TNFα抑制剂优化

Tumor necrosis factor α (TNFα) plays a critical role in inflammatory and autoimmune diseases. While biologic drugs have improved patient outcomes in conditions like rheumatoid arthritis by disrupting

Figshare2025-07-09 更新30

Investigating the effect of NIK SMI1, a small molecule inhibitor of NIK, on TWEAK-stimulated Mouse renal proximal tubule-interstitial epithelial cells (RPTEC). Mus musculus

肾脏炎症机制

小分子药物

Systemic lupus erythematosus (SLE) is often considered a disease driven by autoreactive B cells and anti-nuclear antibodies. However, therapeutic targeting of B cells, for example through BAFF blockad

NIAID Data Ecosystem40

Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway

NOD1信号通路抑制

小分子药物

NOD1 is an intracellular pattern recognition receptor that recognizes diaminopimelic acid (DAP), a peptidoglycan component in gram negative bacteria. Upon ligand binding, NOD1 assembles with receptor-

Figshare2016-01-18 更新30

Modulation of HDR efficiency by cell cycle synchronization

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