Single-cell assay for transposase-accessible chromatin sequencing of human clear cell renal cell carcinoma

In recent years, with the development of single-cell sequencing technology, it has become possible to perform single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq), especially the high-throughput single-cell analysis. Here, we provide a high-quality chromatin accessibility data for ccRCC at single-cell level. Performing high-throughput scATAC-seq on 3 human ccRCC samples (RCC30, RCC61 and RCC76), we obtained a total of 18,703 high quality nuclei and 104,818 unique peaks, including coding, non-coding regions, promoters and enhancers.we demonstrate a complete analysis process for scATAC-seq data, and makes the application more feasible and convenient. ccRCC samples from 3 patients were used for single-cell ATAC sequencing by 10X Genomics.