Effect of Ac2-26 treatment on proinflammatory cytokine secretion.

Peritonitis was induced in rats by i.p. injection of CV (100 μg) or MjTX-II (100 μg) in 0.5 mL of PBS. Control group received i.p. only PBS. Another set of animals were treated i.p. with 1 mg/kg of Ac2-26 peptide after 15 minutes of CV or MjTX-II injection. Peritoneal exudate was collected 4 and 24 hours after peritonitis inductions and cytokine dosages were performed by ELISA, as described in Methods. Values are expressed as the mean ± SEM of cytokine levels (n = 5 rats/group). ND < 31.25 pg/mL (not detected).
* P < 0.05 and
*** P < 0.001 vs control
##P < 0.01 vs CV 4 h.
Effect of Ac2-26 treatment on proinflammatory cytokine secretion.