PGC-1β Promotes Enterocyte Lifespan and Tumorigenesis in the Intestine

ChEBI2015-03-01 更新2026-07-21 收录

肠上皮细胞寿命调控

肿瘤发生机制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-61643 数据链接链接失效反馈

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PGC-1β Promotes Enterocyte Lifespan and Tumorigenesis in the Intestine

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2015-03-01

Gene expression profiling in mouse fibroblast tumors with overexpression of the homeoprotein SIX1

肿瘤发生机制

细胞衰老调控

Six1 is a developmental transcriptional regulator frequently overexpressed in human tumors. Recent results also show that SIX1 acts as a repressor of cell senescence, an antiproliferative response wit

NIAID Data Ecosystem110

p53 amyloid formation induced cellular transformation and tumor formation in xenograft model

p53

肿瘤发生机制

p53 mutation and its subsequent loss of function along with gain of oncogenic functions is associated with cancer. However, the exact mechanism of how altered p53 acts as an oncogene is not clear yet.

NIAID Data Ecosystem50

Identification of a novel TINCR-EGFR signaling pathway loop which initiates receptor tyrosine kinases cascade and confers tumorigenesis in human cancer

癌症信号通路

肿瘤发生机制

RNA sequencing was performed to investigate the potential crosstalk between TINCR and microRNAs. Overall design: microRNA profiles of T47D with TINCR knockdown and scramble were generated by deep sequ

NIAID Data Ecosystem50

NGS-mRNA in lung tissues in RAG1-/- and in RAG1-/- Sgo1-/+ mice

基因表达分析

肿瘤发生机制

We compared lung mRNA expression profiles between RAG1-/- control and RAG1-/- Sgo1-/+ chromosome instability model mice. RAG1-/-Sgo1-/+ mice developed significantly more spontaneous lung tumors. Char

NIAID Data Ecosystem80

YAP1 and PRDM14 converge to regulate cell survival and tumorigenesis

肿瘤发生机制

疾病靶点发现

The transcriptional co-activator YAP1 oncogene is the downstream effector of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. Multiple cancers are dep

NIAID Data Ecosystem50

PGC-1β Promotes Enterocyte Lifespan and Tumorigenesis in the Intestine

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