HVN1968 LINK Metadata Record - Unlocking the potential of polyphenols: A novel approach to target the gut-brain axis

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future. <b>Description: </b>There is growing awareness that gut health is linked to virtually all aspects of human health, from digestive function to metabolic health, immunity, cognition, and mental wellbeing. At the same time, the prevalence of functional gut disorders is on the rise, thought to result from disturbances to the gut-brain axis.The Arepa formula has the potential to provide additive benefits along the gut-brain axis. The Neuroberry® blackcurrant cultivar used in the Arepa formula is unique to Aotearoa and is particularly rich in anthocyanins. Anthocyanins are thought to have a proliferative effect on ‘good’ gut bacteria, yet research in humans has been limited to date. Other plant-derived bio-actives in the Arepa formula are known to target stress, anxiety, cognition, and sleep – all of which can have beneficial effects on the gut microbiota and vice versa.This is a clinical trial assessing impacts of daily consumption of blackcurrant beverage compared to a placebo. A systems approach will be used in this research, providing insight into links between the gut microbiome, blood markers, neurocognitive responses, and diet. The researchers aim to determine whether daily consumption of the Arepa performance beverage has a prebiotic effect, improving the gut microbiota composition and its predicted function. This research also aims to tease apart the role of the gut microbiota in mediating the known neurocognitive benefits of Arepa.