Background: Liver cancer is a lethal cancer type among which hepatocellular carcinoma (HCC) is the most common manifestation globally. Drug resistance is a central problem impeding the efficiency of H

NIAID Data Ecosystem40

Codon Specific Readthrough as a Mechanism of BRCA2 Restoration in Acquired PARP Inhibitor and Chemotherapy Resistance [WES]

癌细胞耐药性

无义密码子通读

Deleterious alterations of the gene encoding BRCA2, a protein involved in homologous recombination (HR), contribute to the pathogenesis of a subset of ovarian, breast, prostate and pancreatic cancers

NIAID Data Ecosystem30

Cytotoxicity of Ruthenium–Arene Complexes Containing β‑Ketoamine Ligands

金属配合物抗癌

癌细胞耐药性

New ruthenium(II) arene derivatives (arene = p-cymene, benzene, hexamethylbenzene) containing β-ketoamine ligands L′ (HL′ in general; in detail, HLph,ph = (4Z)-3-methyl-4-((phenylamino)(phenyl)meth

NIAID Data Ecosystem50

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

癌细胞耐药性

靶向药物开发

This study identifies phosphorylation of SHP2 at tyrosine 62 (pY62) as a conserved mechanism of resistance to allosteric SHP2 inhibitors. By stabilizing an open, active SHP2 conformation, pY62 phenoco

DataCite Commons2026-04-10 更新30

4C-seq at iHUB regions in L3.6pl. 4C-seq at iHUB regions in L3.6pl

资源简介：

相关数据集