EXOC1, BCL2, CCAT2 and CARD8 genes and susceptibility to cervical cancer

The results of the study showed that there was no significant association between the four SNPs and the susceptibility to CC. However, in further stratified analysis, we found that rs13117307 and rs2279115 were significantly related to squamous cell carcinoma antigen (SCC) levels in women with CC, and rs6983267 was significantly related to the menopausal status of women with CC. Specifically, alleles T of rs13117307 and genoytpe AA of rs2279115 when SCC is greater than 0.5 ng/ml will increase the risk of CC. The genotype TG/TG+TT of rs6983267 increases the risk of CC in premenopausal women.