Loss in calving rate in matings between carrier sires and daughters of carrier sires.

*p<0.05, **p<0.01 and ***p<0.001 versus control group (t-test). Haplotypes with significant negative effects on conception rate in both heifers and adult cows in matings at risk are shown in bold type. Nb: number. a: no mating at risk was observed between carriers of these haplotypes and daughters of carrier bulls during the period of time studied (see methods).