Discovery of chromosomal inversions in the mosquito Aedes aegypti

Chromosomal inversions play a fundamental role in evolution and have been shown to be responsible for the epidemiologically important traits in malaria mosquitoes. However, they have never been characterized in the major vector of arboviruses Aedes aegypti because of the poor structure of its polytene chromosomes. In this study, we applied a Hi-C proximity ligation approach to identify chromosomal inversions in 23 recently collected strains of Ae. aegypti from its worldwide distribution, two old laboratory colonies, and Ae. mascarensis. To invetigate chromosomal inversions in Ae. aegypti, we applied Hi-C to identify chromosomal inversions in 25 strains of Ae. aegypti from its world-wide distribution and Ae. mascarensis