miRNA expression in LGCIN outcomes

The goal of this study was to investigate differential regulation of miRNA expression in the cervical tissue of women with low-grade cervical intraepithelial neoplasia (LGCIN, or low grade cervical dysplasia). We compared the miRNA expression profiles of women with LGCIN that progressed to high-grade CIN to the miRNA expression profiles of women with LGCIN that naturally resolved without medical intervention. Study design was case-control without matching. Retrospective chart review was performed to identify women with prior diagnosis of low-grade cervical dysplasia. Women were included if they met inclusion criteria as a Case (women with definitive diagnosis of high-grade dysplasia) or Control (women with significant clinical evidence of dysplasia resolution without medical intervention). Archived punch biopsy specimens with histology consistent with low-grade cervical intraepithelial neoplasia were tested for miRNA expression. Analysis compared Case group to Control group.