ASPIRe Functional Activity Scale Form in Three-Arm Apical Suspension Trial for Post-Hysterectomy Vault Prolapse: Prospective Randomized Trial Involving Sacral Colpopexy, Transvaginal Mesh and Native Tissue Apical Repair

ASPIRe Functional Activity Scale Form, SAS
Study Description
The ASPIRe trial was a multi-site, three-arm randomized controlled clinical trial to determine if apical transvaginal mesh placement is non-inferior to sacral colpopexy for anatomic correction of post-hysterectomy vaginal vault prolapse and to determine if mesh reinforced repairs performed by abdominal or vaginal approach are superior to native tissue vaginal repair. After surgery, participants were followed for up to sixty months and all arms reported sustained improvement in subjective outcomes. Participants who underwent apical repair for vaginal vault prolapse, sacrocolpopexy and transvaginal mesh resulted in similar composite failure rates and both had lower failure rates than native tissue repair. Overall rates of mesh exposure, dyspareunia, and adverse events were low. Adult women 21 years or older with prior total hysterectomy who sought surgical treatment for bothersome bulge symptoms due to prolapse beyond the hymen.