Response of lesions to treatment among subjects treated with imiquimod 5% cream plus pentavalent antimony versus placebo cream plus pentavalent antimony, intention-to-treat analysis (missing = failures).

*Missing includes, at day 20, subjects who did not complete treatment; for all other timepoints, missing also includes those not observed and those lost-to-follow-up.aNot improved/worse is considered a treatment failure and was defined at 1 month post-treatment as an active lesion, unchanged or worse, compared with its characteristics at the start of treatment; at 3 months post- treatment, as a lesion that has been reduced in size by not more than approximately 50%, although having less inflammatory signs with discrete re-epithelialization compared to the start of treatment; at 6 months and later time points, as a lesion that had regressed to a lower clinical stage or the development of a new lesion.bImproved is defined as significant reduction in the size of the lesion at the time of evaluation compared to baseline.cCured is defined as complete re-epithelialization of the lesion without inflammation.1p-values are based on the chi-square analysis comparing cure rates between the two intervention groups, where all those missing and those not improved/worse are considered as failures.