Genome-wide association (GWAS) summary statistics for COVID-19 severity within the DeCOI WGS data

These are the genome-wide association summary statistics for COVID-19 severity within the DeCOI WGS data set from the European subcohort (largest subcohort, n=1,017). For more information see DOI 10.5281/zenodo.10548428 . In short:

Case - control definitions:

A1 (file: DeCOI_EUR_A1.v1.tsv.gz): 272 cases (required mechanical ventilation or died because of COVID-19 = WHO score 6-10); 745 controls (not a case = WHO score 1-5)

B1 (file: DeCOI_EUR_B1.v1.tsv.gz): 655 cases (at least hospitalized = WHO score 4-10); 362 controls (not hospitalized = WHO score 1-3)

Methods:

GWAS was performed using regenie 3.2.4 in simple logistic regression mode (without step 1). Covariates used were sex, age, age², age*sex and the first 10 principal components derived from common variants.

Access:

Access to genome-wide association summary statistics of DeCOI is provided for researchers performing academic research and/or non-commercial use. Users agree to (1) provide a short description of the intended study, (2) not perform any attempts to de-identify study participants, and (3) reference the original study (publication and/or Zenodo doi) when presenting results derived from this dataset.