Cellular and molecular basis of increased renal ammonia excretion in hyperammonemic conditions

First, to characterize experimentally the changes in metabolic processes and gene expression associated with systemic hyperammonemia, in order to better understand the mechanisms responsible for this pathology; second, to construct a predictive a metabolic model of the pathways involved in order to investigate how the development of hyperammonemia can be explained by fundamental shifts in cellular metabolic objectives and gene expression. Overall design: Examination of a hyperammonemic vs normal diet in rodents