Interval running training improves age-related skeletal muscle wasting and bone loss: animal experiment in ovariectomized rats

Various types of running training play an important role in the prevention of age-related diseases, such as sarcopenia and osteoporosis. However, among various types of running training, interval running training affects age-related muscle wasting and bone loss, and its mechanisms are still unclear. This study was to clarify its effect and mechanism in OVX-induced rat models. Interval running training could improve muscle growth and osteogenic differentiation by enhancing the expression of BMPs and SIRTs in aging-induced OVX rats. Therefore, the repetition of low and high intensities within a single exercise bout, such as interval running training, may be recommended for practical intervention to prevent skeletal muscle wasting and bone loss in the elderly.