A Divergent Approach to 3‑Piperidinols: A Concise Syntheses of (+)-Swainsonine and Access to the 1‑Substituted Quinolizidine Skeleton
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https://figshare.com/articles/dataset/A_Divergent_Approach_to_3_Piperidinols_A_Concise_Syntheses_of_Swainsonine_and_Access_to_the_1_Substituted_Quinolizidine_Skeleton/2484502
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资源简介：
Nucleophilic addition of Grignard reagents and organolithium
species
to a 3-silyloxy-3,4,5,6-tetrahydropyridine N-oxide
provides trans-2,3-disubstituted N-hydroxypiperidines exclusively. The application of this methodology
to the preparation of a diversity of useful trans-2-substituted-3-hydroxypiperidines, a concise synthesis of (+)-swainsonine,
and an enantiopure 1-substituted quinolizidine of utility in target-directed
synthesis is reported.
创建时间：
2016-02-20
