Total Synthesis of (−)-Rhodomollanol A
收藏NIAID Data Ecosystem2026-03-11 收录
下载链接：
https://figshare.com/articles/dataset/Total_Synthesis_of_-Rhodomollanol_A/11914353
下载链接
链接失效反馈官方服务：
资源简介：
An asymmetric approach
for the first total synthesis of (−)-rhodomollanol
A, a highly oxidized diterpenoid, is described. The efficient synthetic
strategy features three key transformations: (1) an oxidative dearomatization-induced
(5 + 2) cycloaddition/pinacol-type 1,2-acyl migration cascade to build
up the bicyclo[3.2.1]octane skeleton; (2) a retro-Dieckmann fragmentation/vinylogous Dieckmann cyclization cascade
to assemble the bicyclo[3.3.0]octane subunit; and (3)
a photo-Nazarov cyclization/intramolecular cycloetherification cascade
to forge the 7-oxabicyclo[4.2.1]nonane core structure
of the natural product.
创建时间：
2020-02-24
