Whole transcriptome analysis identifies differentially regulated networks during the proliferation inhibition and megakaryocytic differentiation of AML cell induced by 3,8-Di-O-methylellagic acid 2-O-glucoside (DMAG) derived from Sanguisorba offcinalis L.

We identified the expression profiles of lncRNA, mRNA, miRNA and circRNA by whole-transcriptome sequencing and constructed co-expression network to elucidate the potential mechanisms of 3,8-Di-O-methylellagic acid 2-O-glucoside in anti-AML effect A genome-wide analysis of lncRNAs, mRNA, miRNAs and circRNA expression was detected by whole-transcriptome sequencing on HEL cells after treated with 40 μg/ml DMAG for 3 days, in triplicate.