IRAK4 in complex with compound 20
收藏Protein Data Bank Japan2024-10-16 更新2026-04-25 收录
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IRAK4 in complex with compound 20 Descriptor: (4S)-2-[(1R,4s)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-N-[(8S)-6-methylpyrazolo[1,5-a]pyrimidin-3-yl]-7-[(propan-2-yl)oxy]imidazo[1,2-a]pyrimidine-6-carboxamide, Interleukin-1 receptor-associated kinase 4 Authors: Metrick, C.M, Chodaparambil, J.V. Deposit date: 2023-09-26 Release date: 2024-06-26 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)- N -(6-methylpyrazolo[1,5- a ]pyrimidin-3-yl)imidazo[1,2- a ]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke. J.Med.Chem., 67, 2024
创建时间：
2023-09-26
