Supplemental data - Understanding changes in echocardiographic parameters at different ages following FGR: a systematic review and meta-analysis

Our meta-analysis revealed echocardiographic differences between fetal growth restricted and control offspring in humans during the neonatal period, namely: a reduced left ventricular mass and interventricular septum thickness, reduced mitral annular peak velocity and mitral lateral early diastolic velocity. We were unable to pool echocardiographic parameters in animal studies due to an insufficient number of studies per individual outcome. The few studies on myocardial strain analysis unanimously showed small preclinical changes in FGR offspring.